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Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood. We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonical inducer of astrogliosis,...

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Detalles Bibliográficos
Autores principales: Reichenbach, Nicole, Delekate, Andrea, Plescher, Monika, Schmitt, Franziska, Krauss, Sybille, Blank, Nelli, Halle, Annett, Petzold, Gabor C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365929/
https://www.ncbi.nlm.nih.gov/pubmed/30617153
http://dx.doi.org/10.15252/emmm.201809665