Cargando…

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood. We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonical inducer of astrogliosis,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reichenbach, Nicole, Delekate, Andrea, Plescher, Monika, Schmitt, Franziska, Krauss, Sybille, Blank, Nelli, Halle, Annett, Petzold, Gabor C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365929/ https://www.ncbi.nlm.nih.gov/pubmed/30617153 http://dx.doi.org/10.15252/emmm.201809665

Ejemplares similares

P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model
por: Reichenbach, Nicole, et al.
Publicado: (2018)

Slc1a3-2A-CreERT2 mice reveal unique features of Bergmann glia and augment a growing collection of Cre drivers and effectors in the 129S4 genetic background
por: Kaczmarczyk, Lech, et al.
Publicado: (2021)

Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction
por: Zhang, Zuo, et al.
Publicado: (2021)

NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice
por: Heneka, Michael T., et al.
Publicado: (2012)

Pregabalin improves axon regeneration and motor outcome in a rodent stroke model
por: Kugler, Christof, et al.
Publicado: (2022)

Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?
por: Moulson, Aaron J., et al.
Publicado: (2021)

Curcumin Facilitates Aryl Hydrocarbon Receptor Activation to Ameliorate Inflammatory Astrogliosis
por: Lin, Chun-Hua, et al.
Publicado: (2022)

Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease
por: HU, ZHIYING, et al.
Publicado: (2016)

Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson’s Disease
por: An, Heeyoung, et al.
Publicado: (2021)

MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia
por: Hansen, Jan N., et al.
Publicado: (2022)

Early Activation of STAT3 Regulates Reactive Astrogliosis Induced by Diverse Forms of Neurotoxicity
por: O'Callaghan, James P., et al.
Publicado: (2014)

Astrogenesis versus astrogliosis
por: Koob, Andrew O.
Publicado: (2017)

Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis
por: van den Berge, Simone A., et al.
Publicado: (2012)

Sodium Fluctuations in Astroglia and Their Potential Impact on Astrocyte Function
por: Felix, Lisa, et al.
Publicado: (2020)

Intermittent theta burst stimulation attenuates oxidative stress and reactive astrogliosis in the streptozotocin-induced model of Alzheimer’s disease-like pathology
por: Stanojevic, Jelena B., et al.
Publicado: (2023)

Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer’s continuum
por: Salvadó, Gemma, et al.
Publicado: (2022)

GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice
por: Yuan, Wei, et al.
Publicado: (2021)

Region-specific astrogliosis: differential vessel formation contributes to different patterns of astrogliosis in the cortex and striatum
por: Yang, Haijie, et al.
Publicado: (2020)

Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and ameliorated schizophrenia-like behavior of Gunn rat
por: Limoa, Erlyn, et al.
Publicado: (2016)

Activation of STAT3 Regulates Reactive Astrogliosis and Neuronal Death Induced by AβO Neurotoxicity
por: Toral-Rios, Danira, et al.
Publicado: (2020)

Independent and additive contribution of white matter hyperintensities and Alzheimer’s disease pathology to basal forebrain cholinergic system degeneration
por: Kindler, Christine, et al.
Publicado: (2023)

STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome
por: Arenas, Fabian, et al.
Publicado: (2020)

Long-Term Capsaicin Administration Ameliorates the Dysfunction and Astrogliosis of the Brain in Aged Mice with Missing Maxillary Molars
por: Furukawa, Masae, et al.
Publicado: (2023)

Detection of Aβ plaque-associated astrogliosis in Alzheimer's disease brain by spectroscopic imaging and immunohistochemistry
por: Palombo, Francesca, et al.
Publicado: (2018)

The clock modulator Nobiletin mitigates astrogliosis‐associated neuroinflammation and disease hallmarks in an Alzheimer’s disease model
por: Wirianto, Marvin, et al.
Publicado: (2022)

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia
por: Saggu, Raman, et al.
Publicado: (2016)

Sulfasalazine decreases astrogliosis‐mediated seizure burden
por: Alcoreza, Oscar, et al.
Publicado: (2022)

Imaging of Reactive Astrogliosis by Positron Emission Tomography
por: Harada, Ryuichi, et al.
Publicado: (2022)

Reactive astrogliosis in the era of single-cell transcriptomics
por: Matusova, Zuzana, et al.
Publicado: (2023)

Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer’s disease with multi-modal PET and plasma GFAP
por: Chiotis, Konstantinos, et al.
Publicado: (2023)

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology
por: Krabbe, Grietje, et al.
Publicado: (2013)

Amyloid β‐induced astrogliosis is mediated by β1‐integrin via NADPH oxidase 2 in Alzheimer's disease
por: Wyssenbach, Ane, et al.
Publicado: (2016)

Epothilones Improve Axonal Growth and Motor Outcomes after Stroke in the Adult Mammalian CNS
por: Kugler, Christof, et al.
Publicado: (2020)

Non-invasive quantification of brain tumor-induced astrogliosis
por: Lee, Jisook, et al.
Publicado: (2011)

The Role of Astrogliosis in Formation of the Syrinx in Spinal Cord Injury
por: Kwiecien, Jacek M., et al.
Publicado: (2021)

Corrigendum: Reactive astrogliosis in the era of single-cell transcriptomics
por: Matusova, Zuzana, et al.
Publicado: (2023)

GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer Disease
por: Kamphuis, Willem, et al.
Publicado: (2012)

Mesenchymal Stem Cell Transplantation Promotes Functional Recovery through MMP2/STAT3 Related Astrogliosis after Spinal Cord Injury
por: Kim, Choonghyo, et al.
Publicado: (2019)

3,6′-Dithiopomalidomide Ameliorates Hippocampal Neurodegeneration, Microgliosis and Astrogliosis and Improves Cognitive Behaviors in Rats with a Moderate Traumatic Brain Injury
por: Huang, Pen-Sen, et al.
Publicado: (2021)

Reduction of astrogliosis and microgliosis by cerebrospinal fluid shunting in experimental hydrocephalus
por: Miller, Janet M, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_vqh3417ejsdh8fipfdkt21g6uk