Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway

Chemoresistance is a major therapeutic obstacle in the treatment of human pancreatic ductal adenocarcinoma (PDAC). As an oxidative stress responsive transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the expression of cytoprotective genes. Nrf2 not only plays a critic...

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Detalles Bibliográficos
Autores principales: Zhou, Yunjiang, Zhou, Yang, Yang, Mengdi, Wang, Keke, Liu, Yisi, Zhang, Mingda, Yang, Yunjia, Jin, Chenyu, Wang, Rui, Hu, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365940/
https://www.ncbi.nlm.nih.gov/pubmed/30735911
http://dx.doi.org/10.1016/j.redox.2019.101131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365940/
https://www.ncbi.nlm.nih.gov/pubmed/30735911
http://dx.doi.org/10.1016/j.redox.2019.101131

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