Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy. We have identified compound 14n as promising multitarget small molecule showing strong BuChE inhibition (IC(50) = 1...

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Detalles Bibliográficos
Autores principales: Pachón-Angona, Irene, Refouvelet, Bernard, Andrýs, Rudolf, Martin, Helène, Luzet, Vincent, Iriepa, Isabel, Moraleda, Ignacio, Diez-Iriepa, Daniel, Oset-Gasque, María-Jesús, Marco-Contelles, José, Musilek, Kamil, Ismaili, Lhassane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366423/
https://www.ncbi.nlm.nih.gov/pubmed/30712420
http://dx.doi.org/10.1080/14756366.2018.1545766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366423/
https://www.ncbi.nlm.nih.gov/pubmed/30712420
http://dx.doi.org/10.1080/14756366.2018.1545766

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