The structural basis of unique substrate recognition by Plasmodium thymidylate kinase: Molecular dynamics simulation and inhibitory studies

Plasmodium falciparum thymidylate kinase (PfTMK) showed structural and catalytic distinctions from the host enzyme rendering it a hopeful antiprotozoal drug target. Despite the comprehensive enzymologic, structural, inhibitory and chemical synthesis approaches targeting this enzyme, the elucidation...

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Detalles Bibliográficos
Autores principales: Kandeel, Mahmoud, Kitade, Yukio, Al-Taher, Abdulla, Al-Nazawi, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366710/
https://www.ncbi.nlm.nih.gov/pubmed/30730992
http://dx.doi.org/10.1371/journal.pone.0212065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366710/
https://www.ncbi.nlm.nih.gov/pubmed/30730992
http://dx.doi.org/10.1371/journal.pone.0212065

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