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The structural basis of unique substrate recognition by Plasmodium thymidylate kinase: Molecular dynamics simulation and inhibitory studies

Plasmodium falciparum thymidylate kinase (PfTMK) showed structural and catalytic distinctions from the host enzyme rendering it a hopeful antiprotozoal drug target. Despite the comprehensive enzymologic, structural, inhibitory and chemical synthesis approaches targeting this enzyme, the elucidation...

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Detalles Bibliográficos
Autores principales:	Kandeel, Mahmoud, Kitade, Yukio, Al-Taher, Abdulla, Al-Nazawi, Mohammed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366710/ https://www.ncbi.nlm.nih.gov/pubmed/30730992 http://dx.doi.org/10.1371/journal.pone.0212065

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