Evidence for Weak Selective Constraint on Human Gene Expression

Gene expression variation is a major contributor to phenotypic variation in human complex traits. Selection on complex traits may therefore be reflected in constraint on gene expression. Here, we explore the effects of stabilizing selection on cis-regulatory genetic variation in humans. We analyze p...

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Detalles Bibliográficos
Autores principales: Glassberg, Emily C., Gao, Ziyue, Harpak, Arbel, Lan, Xun, Pritchard, Jonathan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2019
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366908/
https://www.ncbi.nlm.nih.gov/pubmed/30554168
http://dx.doi.org/10.1534/genetics.118.301833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366908/
https://www.ncbi.nlm.nih.gov/pubmed/30554168
http://dx.doi.org/10.1534/genetics.118.301833

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