Impairment of hypoxia-induced angiogenesis by LDL involves a HIF-centered signaling network linking inflammatory TNFα and angiogenic VEGF

Hypoxia inducible factors (HIFs) mediate angiogenesis via up-regulation of various pro-angiogenic factors (particularly VEGF) in response to hypoxia. Here, we report that hypoxia unexpectedly induced robust production of the pro-inflammatory factor TNFα by endothelial cells (ECs), suggesting an auto...

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Detalles Bibliográficos
Autores principales: Jin, Fengyan, Zheng, Xiangyu, Yang, Yanping, Yao, Gang, Ye, Long, Doeppner, Thorsten R., Hermann, Dirk M., Wang, Haifeng, Dai, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366960/
https://www.ncbi.nlm.nih.gov/pubmed/30659163
http://dx.doi.org/10.18632/aging.101726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366960/
https://www.ncbi.nlm.nih.gov/pubmed/30659163
http://dx.doi.org/10.18632/aging.101726

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