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Impairment of hypoxia-induced angiogenesis by LDL involves a HIF-centered signaling network linking inflammatory TNFα and angiogenic VEGF

Hypoxia inducible factors (HIFs) mediate angiogenesis via up-regulation of various pro-angiogenic factors (particularly VEGF) in response to hypoxia. Here, we report that hypoxia unexpectedly induced robust production of the pro-inflammatory factor TNFα by endothelial cells (ECs), suggesting an auto...

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Detalles Bibliográficos
Autores principales:	Jin, Fengyan, Zheng, Xiangyu, Yang, Yanping, Yao, Gang, Ye, Long, Doeppner, Thorsten R., Hermann, Dirk M., Wang, Haifeng, Dai, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366960/ https://www.ncbi.nlm.nih.gov/pubmed/30659163 http://dx.doi.org/10.18632/aging.101726

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