S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α

Senescent cells display the senescence-associated secretory phenotype (SASP) which plays important roles in cancer, aging, etc. Cell surface-bound IL-1α is a crucial SASP factor and acts as an upstream regulator to induce NF-κB activity and subsequent SASP genes transcription. IL-1α exports to cell...

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Detalles Bibliográficos
Autores principales: Su, Yuanyuan, Xu, Chenzhong, Sun, Zhaomeng, Liang, Yao, Li, Guodong, Tong, Tanjun, Chen, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366962/
https://www.ncbi.nlm.nih.gov/pubmed/30670674
http://dx.doi.org/10.18632/aging.101760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366962/
https://www.ncbi.nlm.nih.gov/pubmed/30670674
http://dx.doi.org/10.18632/aging.101760

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