Cargando…

Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro

Abnormalities in tricarboxylic acid (TCA) cycle function were related to a variety of pathological processes. Fumarate hydratase (FH) is a required enzyme in the TCA cycle. To explore the general influence of FH knockout, we isolated FH(+/–) rat and normal rat lung fibroblasts and cultured these cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Zhirui, Li, Lifeng, Li, Xiaoli, Zhang, Meng, Dou, Mengmeng, Zhao, Jing, Cao, Jing, Deng, Xiaoming, Zhang, Mingzhi, Li, Huixiang, Suo, Zhenhe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366963/ https://www.ncbi.nlm.nih.gov/pubmed/30668541 http://dx.doi.org/10.18632/aging.101761

Ejemplares similares

Generation of an oxoglutarate dehydrogenase knockout rat model and the effect of a high-fat diet
por: Fan, Zhirui, et al.
Publicado: (2018)

HIF and fumarate hydratase in renal cancer
por: Sudarshan, S, et al.
Publicado: (2007)

Structural basis of fumarate hydratase deficiency
por: Picaud, Sarah, et al.
Publicado: (2011)

High SRPX2 protein expression predicts unfavorable clinical outcome in patients with prostate cancer
por: Zhang, Meng, et al.
Publicado: (2018)

PDHA1 Gene Knockout In Human Esophageal Squamous Cancer Cells Resulted In Greater Warburg Effect And Aggressive Features In Vitro And In Vivo
por: Liu, Lan, et al.
Publicado: (2019)

Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses
por: Li, Xiaoli, et al.
Publicado: (2016)

Fumarate hydratase deficiency induces chronic myeloid leukemia progression
por: Li, Shan, et al.
Publicado: (2019)

Generation of TALEN-mediated FH knockout rat model
por: Yu, Dandan, et al.
Publicado: (2016)

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
por: Ternette, Nicola, et al.
Publicado: (2013)

Identification of Fumarate Hydratase Inhibitors with Nutrient-Dependent Cytotoxicity
por: Takeuchi, Toshifumi, et al.
Publicado: (2014)

Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism
por: Valcarcel-Jimenez, Lorea, et al.
Publicado: (2023)

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
por: Tyrakis, Petros A., et al.
Publicado: (2017)

MED12 mutations and fumarate hydratase inactivation in uterine adenomyomas
por: Heikkinen, Tuomas, et al.
Publicado: (2018)

Uterine leiomyoma with fumarate hydratase deficiency: A case report
por: Huang, Yan, et al.
Publicado: (2021)

The Waldo of fibroids under the microscope: fumarate hydratase–deficient leiomyomata
por: Punjabi, Lavisha S., et al.
Publicado: (2022)

How a woman’s myomectomy saved her father’s life: evidence of fumarate hydratase–deficient uterine leiomyoma and early detection of germline variants in fumarate hydratase
por: Rivera-Cruz, Greysha, et al.
Publicado: (2021)

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes
por: Adam, Julie, et al.
Publicado: (2017)

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
por: Zheng, Liang, et al.
Publicado: (2013)

Cutaneous and uterine leiomyomatosis and ovarian cystadenoma associated with deficiency of fumarate hydratase
por: Hüller, Cornelia, et al.
Publicado: (2011)

Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells
por: Gonçalves, Emanuel, et al.
Publicado: (2018)

Synthetically Lethal Interactions of Heme Oxygenase-1 and Fumarate Hydratase Genes
por: Podkalicka, Paulina, et al.
Publicado: (2020)

Targeting strategies in the treatment of fumarate hydratase deficient renal cell carcinoma
por: Lindner, Andrea Katharina, et al.
Publicado: (2022)

A Clinicopathologic and Molecular Analysis of Fumarate Hydratase–deficient Pheochromocytoma and Paraganglioma
por: Fuchs, Talia L., et al.
Publicado: (2023)

Fumarate hydratase: a new checkpoint of metabolic regulation in inflammatory macrophages
por: Jeridi, Aicha, et al.
Publicado: (2023)

Investigating Fumarate Hydratase-Deficient Uterine Fibroids: A Case Series
por: Alkhrait, Samar, et al.
Publicado: (2023)

Fumarate hydratase inhibition activates innate immunity via mitochondrial nucleic acid release
por: Li, Xiang, et al.
Publicado: (2023)

A Case of Reed Syndrome with a Novel Mutation in the Fumarate Hydratase Gene
por: Laufer, Christin B., et al.
Publicado: (2013)

Fumarate Hydratase–deficient Uterine Leiomyomas Occur in Both the Syndromic and Sporadic Settings
por: Harrison, Wesley J., et al.
Publicado: (2016)

Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver
por: Liu, Shuang, et al.
Publicado: (2016)

A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia
por: Adam, Julie, et al.
Publicado: (2013)

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions
por: Guitart, Amelie V., et al.
Publicado: (2017)

Reply of the Authors: The Waldo of fibroids under the microscope: fumarate hydratase-deficient leiomyomata
por: Rivera-Cruz, Greysha, et al.
Publicado: (2022)

Fumarate hydratase-deficient renal cell carcinoma in extended remission with bevacizumab and erlotinib
por: Tomar, Shubham, et al.
Publicado: (2022)

Structure of fumarate hydratase from Rickettsia prowazekii, the agent of typhus and suspected relative of the mitochondria
por: Phan, Isabelle, et al.
Publicado: (2011)

Rutaecarpine induces the differentiation of triple-negative breast cancer cells through inhibiting fumarate hydratase
por: Lei, Jie, et al.
Publicado: (2023)

Promoting role of pentraxin-3 in esophageal squamous cell carcinoma
por: Fan, Zhirui, et al.
Publicado: (2022)

Erratum to: Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver
por: Liu, Shuang, et al.
Publicado: (2016)

Imaging features of fumarate hydratase-deficient renal cell carcinomas: a retrospective study
por: Nikolovski, Ines, et al.
Publicado: (2021)

Recurrent Cushing Syndrome From Metastatic Adrenocortical Carcinoma With Fumarate Hydratase Allelic Variant
por: Silverman, Emily, et al.
Publicado: (2022)

Fumarate hydratase-deficient renal cell carcinoma: a case report and review of the literature
por: Lv, Yanting, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_em8rau12iaipqb9haga486q35m