Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

Geniposide, an iridoid glycoside extract from the gardenia fruit, is used in traditional Chinese medicine to alleviate symptoms of liver and inflammatory diseases. Geniposide activates GLP-1 receptors, known to modulate the activity of mechanistic target of rapamycin (mTOR), a key kinase regulating...

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Detalles Bibliográficos
Autores principales: Zhang, Zhihua, Wang, Xiaojian, Zhang, Di, Liu, Yueze, Li, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366989/
https://www.ncbi.nlm.nih.gov/pubmed/30684442
http://dx.doi.org/10.18632/aging.101759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366989/
https://www.ncbi.nlm.nih.gov/pubmed/30684442
http://dx.doi.org/10.18632/aging.101759

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