Super-Mendelian inheritance mediated by CRISPR/Cas9 in the female mouse germline

A gene drive biases the transmission of one of two copies of a gene such that it is inherited more frequently than by random segregation. Highly efficient gene drive systems were recently developed in insects, which leverage the sequence-targeted DNA cleavage activity of CRISPR/Cas9 and endogenous h...

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Detalles Bibliográficos
Autores principales: Grunwald, Hannah A., Gantz, Valentino M., Poplawski, Gunnar, Xu, Xiang-ru S., Bier, Ethan, Cooper, Kimberly L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367021/
https://www.ncbi.nlm.nih.gov/pubmed/30675057
http://dx.doi.org/10.1038/s41586-019-0875-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367021/
https://www.ncbi.nlm.nih.gov/pubmed/30675057
http://dx.doi.org/10.1038/s41586-019-0875-2

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