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Super-Mendelian inheritance mediated by CRISPR/Cas9 in the female mouse germline
A gene drive biases the transmission of one of two copies of a gene such that it is inherited more frequently than by random segregation. Highly efficient gene drive systems were recently developed in insects, which leverage the sequence-targeted DNA cleavage activity of CRISPR/Cas9 and endogenous h...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367021/ https://www.ncbi.nlm.nih.gov/pubmed/30675057 http://dx.doi.org/10.1038/s41586-019-0875-2 |