Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors

GPR139 is a Gq‐coupled receptor activated by the essential amino acids L‐tryptophan (L‐Trp) and L‐phenylalanine (L‐Phe). We carried out mutagenesis studies of the human GPR139 receptor to identify the critical structural motifs required for GPR139 activation. We applied site‐directed and high throug...

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Detalles Bibliográficos
Autores principales: Wang, Lien, Lee, Grace, Shih, Amy, Kuei, Chester, Nepomuceno, Diane, Wennerholm, Michelle, Fan, Frances, Wu, Jiejun, Bonaventure, Pascal, Lovenberg, Timothy W., Liu, Changlu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367278/
https://www.ncbi.nlm.nih.gov/pubmed/30774960
http://dx.doi.org/10.1002/prp2.466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367278/
https://www.ncbi.nlm.nih.gov/pubmed/30774960
http://dx.doi.org/10.1002/prp2.466

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