Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586

The mupirocin trans-AT polyketide synthase pathway, provides a model system for manipulation of antibiotic biosynthesis. Its final phase involves removal of the tertiary hydroxyl group from pseudomonic acid B, PA-B, producing the fully active PA-A in a complex series of steps. To further clarify req...

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Detalles Bibliográficos
Autores principales: Connolly, Jack A., Wilson, Amber, Macioszek, Malgorzata, Song, Zhongshu, Wang, Luoyi, Mohammad, Hadi H., Yadav, Mukul, di Martino, Maura, Miller, Claire E., Hothersall, Joanne, Haines, Anthony S., Stephens, Elton R., Crump, Matthew P., Willis, Christine L., Simpson, Thomas J., Winn, Peter J., Thomas, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367315/
https://www.ncbi.nlm.nih.gov/pubmed/30733464
http://dx.doi.org/10.1038/s41598-018-38038-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367315/
https://www.ncbi.nlm.nih.gov/pubmed/30733464
http://dx.doi.org/10.1038/s41598-018-38038-9

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