Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

Neurokinin 1 receptor (NK1R) has key regulating functions in the central and peripheral nervous systems, and NK1R antagonists such as aprepitant have been approved for treating chemotherapy-induced nausea and vomiting. However, the lack of data on NK1R structure and biochemistry has limited further...

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Detalles Bibliográficos
Autores principales: Chen, Shuanghong, Lu, Mengjie, Liu, Dongsheng, Yang, Lingyun, Yi, Cuiying, Ma, Limin, Zhang, Hui, Liu, Qing, Frimurer, Thomas M., Wang, Ming-Wei, Schwartz, Thue W., Stevens, Raymond C., Wu, Beili, Wüthrich, Kurt, Zhao, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367319/
https://www.ncbi.nlm.nih.gov/pubmed/30733446
http://dx.doi.org/10.1038/s41467-019-08568-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367319/
https://www.ncbi.nlm.nih.gov/pubmed/30733446
http://dx.doi.org/10.1038/s41467-019-08568-5

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