Evaluation of site-specific homologous recombination activity of BRCA1 by direct quantitation of gene editing efficiency

Homologous recombination (HR) contributes to the repair of DNA double-strand breaks (DSBs) and inter-strand crosslinks. The HR activity in cancer cells can be used to predict their sensitivity to DNA-damaging agents that cause these damages. To evaluate HR activity, we developed a system called Assa...

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Detalles Bibliográficos
Autores principales: Yoshino, Yuki, Endo, Shino, Chen, Zhenghao, Qi, Huicheng, Watanabe, Gou, Chiba, Natsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367331/
https://www.ncbi.nlm.nih.gov/pubmed/30733539
http://dx.doi.org/10.1038/s41598-018-38311-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367331/
https://www.ncbi.nlm.nih.gov/pubmed/30733539
http://dx.doi.org/10.1038/s41598-018-38311-x

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