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Evaluation of site-specific homologous recombination activity of BRCA1 by direct quantitation of gene editing efficiency
Homologous recombination (HR) contributes to the repair of DNA double-strand breaks (DSBs) and inter-strand crosslinks. The HR activity in cancer cells can be used to predict their sensitivity to DNA-damaging agents that cause these damages. To evaluate HR activity, we developed a system called Assa...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367331/ https://www.ncbi.nlm.nih.gov/pubmed/30733539 http://dx.doi.org/10.1038/s41598-018-38311-x |