Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs

Flavocytochrome P450 BM3 is a natural fusion protein constructed of cytochrome P450 and NADPH-cytochrome P450 reductase domains. P450 BM3 binds and oxidizes several mid- to long-chain fatty acids, typically hydroxylating these lipids at the ω-1, ω-2 and ω-3 positions. However, protein engineering ha...

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Detalles Bibliográficos
Autores principales: Jeffreys, Laura N., Poddar, Harshwardhan, Golovanova, Marina, Levy, Colin W., Girvan, Hazel M., McLean, Kirsty J., Voice, Michael W., Leys, David, Munro, Andrew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367340/
https://www.ncbi.nlm.nih.gov/pubmed/30733479
http://dx.doi.org/10.1038/s41598-018-37330-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367340/
https://www.ncbi.nlm.nih.gov/pubmed/30733479
http://dx.doi.org/10.1038/s41598-018-37330-y

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