Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Insulin-induced gene (Insig) negatively regulates SREBP-mediated de novo fatty acid synthesis in the liver. However, the upstream regulation of Insig is incompletely understood. Here we report that AMPK interacts with and mediates phosphorylation of Insig. Thr222 phosphorylation following AMPK activ...

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Detalles Bibliográficos
Autores principales: Han, Yamei, Hu, Zhimin, Cui, Aoyuan, Liu, Zhengshuai, Ma, Fengguang, Xue, Yaqian, Liu, Yuxiao, Zhang, Feifei, Zhao, Zehua, Yu, Yanyan, Gao, Jing, Wei, Chun, Li, Jingya, Fang, Jing, Li, Jia, Fan, Jian-Gao, Song, Bao-Liang, Li, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367348/
https://www.ncbi.nlm.nih.gov/pubmed/30733434
http://dx.doi.org/10.1038/s41467-019-08585-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367348/
https://www.ncbi.nlm.nih.gov/pubmed/30733434
http://dx.doi.org/10.1038/s41467-019-08585-4

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