eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes

We have developed a transgenic mouse model of Type 1 Diabetes (T1D) in which human GAD65 is expressed in pancreatic β-cells, and human MHC-II is expressed on antigen presenting cells. Induced GAD65 antigen presentation activates T-cells, which initiates the downstream events leading to diabetes. In...

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Detalles Bibliográficos
Autores principales: Imam, Shahnawaz, Prathibha, R., Dar, Pervaiz, Almotah, Khalil, Al-Khudhair, Ahmed, Hasan, Syed Abdul-Moiz, Salim, Nancy, Jilani, Talha Naser, Mirmira, Raghavendra G., Jaume, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367423/
https://www.ncbi.nlm.nih.gov/pubmed/30733517
http://dx.doi.org/10.1038/s41598-018-38341-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367423/
https://www.ncbi.nlm.nih.gov/pubmed/30733517
http://dx.doi.org/10.1038/s41598-018-38341-5

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