Simultaneous targeting of linked loci in mouse embryos using base editing

A particular challenge in genome engineering has been the simultaneous introduction of mutations into linked (located on the same chromosome) loci. Although CRISPR/Cas9 has been widely used to mutate individual sites, its application in simultaneously targeting of linked loci is limited as multiple...

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Detalles Bibliográficos
Autores principales: Lee, Hye Kyung, Willi, Michaela, Smith, Harold E., Miller, Shannon M., Liu, David R., Liu, Chengyu, Hennighausen, Lothar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367434/
https://www.ncbi.nlm.nih.gov/pubmed/30733567
http://dx.doi.org/10.1038/s41598-018-33533-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367434/
https://www.ncbi.nlm.nih.gov/pubmed/30733567
http://dx.doi.org/10.1038/s41598-018-33533-5

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