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UDP-glucose Dehydrogenase: The First-step Oxidation Is an NAD(+)-dependent Bimolecular Nucleophilic Substitution Reaction (S(N)2)
UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid by NAD(+)-dependent two-fold oxidation. Despite extensive investigation into the catalytic mechanism of UGDH, the previously proposed mechanisms regarding the first-step oxidation are somewhat controversi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Ivyspring International Publisher
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367545/ https://www.ncbi.nlm.nih.gov/pubmed/30745825 http://dx.doi.org/10.7150/ijbs.28904 |