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UDP-glucose Dehydrogenase: The First-step Oxidation Is an NAD(+)-dependent Bimolecular Nucleophilic Substitution Reaction (S(N)2)

UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid by NAD(+)-dependent two-fold oxidation. Despite extensive investigation into the catalytic mechanism of UGDH, the previously proposed mechanisms regarding the first-step oxidation are somewhat controversi...

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Detalles Bibliográficos
Autores principales:	Chen, Jun, Yu, Yang, Gao, Jiaojiao, Yang, Shulin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Short Research Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367545/ https://www.ncbi.nlm.nih.gov/pubmed/30745825 http://dx.doi.org/10.7150/ijbs.28904

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