Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2

Metformin, a common therapeutics for type 2 diabetics, was recently demonstrated to possess antitumor activity in various cancer types. However, its therapy effect in renal cell carcinoma (RCC) still remains controversial. In this study, we found that metformin treatment in RCC cells lead to activat...

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Detalles Bibliográficos
Autores principales: Liu, Meihan, Zhang, Zhuo, Wang, Hui, Chen, Xiaoliang, Jin, Chunxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367591/
https://www.ncbi.nlm.nih.gov/pubmed/30745848
http://dx.doi.org/10.7150/ijbs.29689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367591/
https://www.ncbi.nlm.nih.gov/pubmed/30745848
http://dx.doi.org/10.7150/ijbs.29689

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