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Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages

BACKGROUND: Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression. The role of the host mRNA decay pathways in macrophages in the context of human immunodef...

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Detalles Bibliográficos
Autores principales: Rao, Shringar, Amorim, Raquel, Niu, Meijuan, Breton, Yann, Tremblay, Michel J., Mouland, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367771/
https://www.ncbi.nlm.nih.gov/pubmed/30732620
http://dx.doi.org/10.1186/s12977-019-0465-2