Regional methylome profiling reveals dynamic epigenetic heterogeneity and convergent hypomethylation of stem cell quiescence-associated genes in breast cancer following neoadjuvant chemotherapy

BACKGROUND: Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ~ 30% of patients with breast cancer. However, aberrant DNA methylation alterations are frequent events during breast cancer progression and acquisition of chemoresistance. We aimed to characterize the inter...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Yumei, Huang, Juan, Tang, Yi, Luo, Xitu, Ge, Lingxia, Sheng, Xiujie, Sun, Xiaofang, Chen, Yaoyong, Zhu, Detu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367786/
https://www.ncbi.nlm.nih.gov/pubmed/30774927
http://dx.doi.org/10.1186/s13578-019-0278-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367786/
https://www.ncbi.nlm.nih.gov/pubmed/30774927
http://dx.doi.org/10.1186/s13578-019-0278-y

Ejemplares similares