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Regional methylome profiling reveals dynamic epigenetic heterogeneity and convergent hypomethylation of stem cell quiescence-associated genes in breast cancer following neoadjuvant chemotherapy

BACKGROUND: Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ~ 30% of patients with breast cancer. However, aberrant DNA methylation alterations are frequent events during breast cancer progression and acquisition of chemoresistance. We aimed to characterize the inter...

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Detalles Bibliográficos
Autores principales:	Luo, Yumei, Huang, Juan, Tang, Yi, Luo, Xitu, Ge, Lingxia, Sheng, Xiujie, Sun, Xiaofang, Chen, Yaoyong, Zhu, Detu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367786/ https://www.ncbi.nlm.nih.gov/pubmed/30774927 http://dx.doi.org/10.1186/s13578-019-0278-y

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