TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzheimer’s disease (AD), which may compromise the function of BDNF upon neuronal activity and survival. Accordingly, decreased levels of BDNF and its tropomyosin-receptor kinase B-full-length (TrkB-FL) ha...

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Detalles Bibliográficos
Autores principales: Fonseca-Gomes, João, Jerónimo-Santos, André, Lesnikova, Angelina, Casarotto, Plinio, Castrén, Eero, Sebastião, Ana M., Diógenes, Maria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367892/
https://www.ncbi.nlm.nih.gov/pubmed/30774582
http://dx.doi.org/10.3389/fnmol.2019.00004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367892/
https://www.ncbi.nlm.nih.gov/pubmed/30774582
http://dx.doi.org/10.3389/fnmol.2019.00004

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