The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice

CLEC16A locus polymorphisms have been associated with several autoimmune diseases. We overexpressed CLEC16A in YTS natural killer (NK) cells and observed reduced NK cell cytotoxicity and IFN-γ release, delayed dendritic cell (DC) maturation, decreased conjugate formation, cell-surface receptor downr...

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Detalles Bibliográficos
Autores principales: Pandey, Rahul, Bakay, Marina, Hain, Heather S., Strenkowski, Bryan, Yermakova, Anastasiya, Kushner, Jake A., Orange, Jordan S., Hakonarson, Hakon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367972/
https://www.ncbi.nlm.nih.gov/pubmed/30774629
http://dx.doi.org/10.3389/fimmu.2019.00068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367972/
https://www.ncbi.nlm.nih.gov/pubmed/30774629
http://dx.doi.org/10.3389/fimmu.2019.00068

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