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Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells

It is common practice for researchers to use antibodies to remove a specific cell type to infer its function. However, it is difficult to completely eliminate a cell type and there is often limited or no information as to how the cells which survive depletion are affected. This is particularly impor...

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Detalles Bibliográficos
Autores principales: Cross, Eric W., Blain, Trevor J., Mathew, Divij, Kedl, Ross M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368275/
https://www.ncbi.nlm.nih.gov/pubmed/30735510
http://dx.doi.org/10.1371/journal.pone.0211446