GluClR-mediated inhibitory postsynaptic currents reveal targets for ivermectin and potential mechanisms of ivermectin resistance

Glutamate-gated chloride channel receptors (GluClRs) mediate inhibitory neurotransmission at invertebrate synapses and are primary targets of parasites that impact drastically on agriculture and human health. Ivermectin (IVM) is a broad-spectrum pesticide that binds and potentiates GluClR activity....

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Detalles Bibliográficos
Autores principales: Atif, Mohammed, Smith, Jennifer J., Estrada-Mondragon, Argel, Xiao, Xue, Salim, Angela A., Capon, Robert J., Lynch, Joseph W., Keramidas, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368337/
https://www.ncbi.nlm.nih.gov/pubmed/30695069
http://dx.doi.org/10.1371/journal.ppat.1007570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368337/
https://www.ncbi.nlm.nih.gov/pubmed/30695069
http://dx.doi.org/10.1371/journal.ppat.1007570

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