A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration

A fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined orientation of each transmembrane segment. Despite this, it remains unclear how cells detect and handle failures in this process. Here we show that single point mutations in the membrane prot...

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Detalles Bibliográficos
Autores principales: Coelho, João P. L., Stahl, Matthias, Bloemeke, Nicolas, Meighen-Berger, Kevin, Alvira, Carlos Piedrafita, Zhang, Zai-Rong, Sieber, Stephan A., Feige, Matthias J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368539/
https://www.ncbi.nlm.nih.gov/pubmed/30737405
http://dx.doi.org/10.1038/s41467-019-08632-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368539/
https://www.ncbi.nlm.nih.gov/pubmed/30737405
http://dx.doi.org/10.1038/s41467-019-08632-0

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