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A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
A fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined orientation of each transmembrane segment. Despite this, it remains unclear how cells detect and handle failures in this process. Here we show that single point mutations in the membrane prot...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368539/ https://www.ncbi.nlm.nih.gov/pubmed/30737405 http://dx.doi.org/10.1038/s41467-019-08632-0 |