Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

Corticosteroids are host-directed drugs with proven beneficial effect on survival of tuberculosis (TB) patients, but their precise mechanisms of action in this disease remain largely unknown. Here we show that corticosteroids such as dexamethasone inhibit necrotic cell death of cells infected with M...

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Detalles Bibliográficos
Autores principales: Gräb, Jessica, Suárez, Isabelle, van Gumpel, Edeltraud, Winter, Sandra, Schreiber, Fynn, Esser, Anna, Hölscher, Christoph, Fritsch, Melanie, Herb, Marc, Schramm, Michael, Wachsmuth, Laurens, Pallasch, Christian, Pasparakis, Manolis, Kashkar, Hamid, Rybniker, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368550/
https://www.ncbi.nlm.nih.gov/pubmed/30737374
http://dx.doi.org/10.1038/s41467-019-08405-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368550/
https://www.ncbi.nlm.nih.gov/pubmed/30737374
http://dx.doi.org/10.1038/s41467-019-08405-9

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