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Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition
Corticosteroids are host-directed drugs with proven beneficial effect on survival of tuberculosis (TB) patients, but their precise mechanisms of action in this disease remain largely unknown. Here we show that corticosteroids such as dexamethasone inhibit necrotic cell death of cells infected with M...
Autores principales: | Gräb, Jessica, Suárez, Isabelle, van Gumpel, Edeltraud, Winter, Sandra, Schreiber, Fynn, Esser, Anna, Hölscher, Christoph, Fritsch, Melanie, Herb, Marc, Schramm, Michael, Wachsmuth, Laurens, Pallasch, Christian, Pasparakis, Manolis, Kashkar, Hamid, Rybniker, Jan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368550/ https://www.ncbi.nlm.nih.gov/pubmed/30737374 http://dx.doi.org/10.1038/s41467-019-08405-9 |
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