Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease

Fas Ligand (FasL) and Fas (APO-1/CD95) are members of the TNFR superfamily and may trigger apoptosis. Here, we aimed to elucidate the functional role of Fas signaling in an experimental model of chronic liver disease, the hepatocyte-specific NEMO knockout (NEMO(Δhepa)) mice. We generated NEMO(Δhepa)...

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Detalles Bibliográficos
Autores principales: Cubero, Francisco Javier, Woitok, Marius Maximilian, Zoubek, Miguel E., de Bruin, Alain, Hatting, Maximilian, Trautwein, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368573/
https://www.ncbi.nlm.nih.gov/pubmed/30737368
http://dx.doi.org/10.1038/s41419-019-1391-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368573/
https://www.ncbi.nlm.nih.gov/pubmed/30737368
http://dx.doi.org/10.1038/s41419-019-1391-x

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