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The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLAR(L) in human lung cancer cells
BACKGROUND: CFLAR(L), also known as c-FLIP(L), is a critical anti-apoptotic protein that inhibits activation of caspase 8 in mammalian cells. Previous studies have shown that arginine 122 of CFLAR(L) can be mono-methylated. However, the precise role of arginine methyltransferase of CFLAR(L) remains...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368745/ https://www.ncbi.nlm.nih.gov/pubmed/30736843 http://dx.doi.org/10.1186/s13046-019-1064-8 |