TNF-α/STAT3 pathway epigenetically upregulates Nav1.6 expression in DRG and contributes to neuropathic pain induced by L5-VRT

BACKGROUND: Studies showed that upregulation of Nav1.6 increased the neuronal excitability and participated in neuropathic pain in the dorsal root ganglion (DRG). However, the molecular mechanisms underlying Nav1.6 upregulation were not reported yet. METHODS: The paw withdrawal threshold was measure...

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Detalles Bibliográficos
Autores principales: Ding, Huan-Huan, Zhang, Su-Bo, Lv, You-You, Ma, Chao, Liu, Meng, Zhang, Kui-Bo, Ruan, Xiang-Cai, Wei, Jia-You, Xin, Wen-Jun, Wu, Shao-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368780/
https://www.ncbi.nlm.nih.gov/pubmed/30736806
http://dx.doi.org/10.1186/s12974-019-1421-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368780/
https://www.ncbi.nlm.nih.gov/pubmed/30736806
http://dx.doi.org/10.1186/s12974-019-1421-8

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