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Semaphorin4A causes loss of mature oligodendrocytes and demyelination in vivo

BACKGROUND: Inappropriate contact between the immune system and the central nervous system is thought to be a cause of demyelination. We previously reported the ability of the class IV semaphorin, Semaphorin4A (Sema4A), to induce apoptosis in human oligodendrocytes; however, these results have yet t...

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Detalles Bibliográficos
Autores principales: Chiou, Brian, Neely, Elizabeth, Kallianpur, Asha, Connor, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368782/
https://www.ncbi.nlm.nih.gov/pubmed/30736794
http://dx.doi.org/10.1186/s12974-019-1420-9