Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu

Bufotalin (BFT), one of the naturally occurring bufodienolides, has multiple pharmacological and toxicological effects including antitumor activity and cardiotoxicity. This study aimed to character the metabolic pathway(s) of BFT and to identify the key drug metabolizing enzyme(s) responsible for he...

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Detalles Bibliográficos
Autores principales: Dai, Zi-Ru, Ning, Jing, Sun, Gui-Bo, Wang, Ping, Zhang, Feng, Ma, Hong-Ying, Zou, Li-Wei, Hou, Jie, Wu, Jing-Jing, Ge, Guang-Bo, Sun, Xiao-Bo, Yang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369212/
https://www.ncbi.nlm.nih.gov/pubmed/30778299
http://dx.doi.org/10.3389/fphar.2019.00052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369212/
https://www.ncbi.nlm.nih.gov/pubmed/30778299
http://dx.doi.org/10.3389/fphar.2019.00052

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