Anomalous Dense Liquid Condensates Host the Nucleation of Tumor Suppressor p53 Fibrils

About half of human cancers are associated with mutations of the tumor suppressor p53. Gained oncogenic functions of the mutants have been related to aggregation behaviors of wild-type and mutant p53. The thermodynamic and kinetic mechanisms of p53 aggregation are poorly understood. Here we find tha...

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Detalles Bibliográficos
Autores principales: Safari, Mohammad S., Wang, Zhiqing, Tailor, Kunaal, Kolomeisky, Anatoly B., Conrad, Jacinta C., Vekilov, Peter G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369220/
https://www.ncbi.nlm.nih.gov/pubmed/30739016
http://dx.doi.org/10.1016/j.isci.2019.01.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369220/
https://www.ncbi.nlm.nih.gov/pubmed/30739016
http://dx.doi.org/10.1016/j.isci.2019.01.027

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