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Anomalous Dense Liquid Condensates Host the Nucleation of Tumor Suppressor p53 Fibrils
About half of human cancers are associated with mutations of the tumor suppressor p53. Gained oncogenic functions of the mutants have been related to aggregation behaviors of wild-type and mutant p53. The thermodynamic and kinetic mechanisms of p53 aggregation are poorly understood. Here we find tha...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369220/ https://www.ncbi.nlm.nih.gov/pubmed/30739016 http://dx.doi.org/10.1016/j.isci.2019.01.027 |