Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics

BACKGROUND & AIMS: A generalized human pacemaking syndrome, chronic atrial and intestinal dysrhythmia (CAID) (OMIM 616201), is caused by a homozygous SGO1 mutation (K23E), leading to chronic intestinal pseudo-obstruction and arrhythmias. Because CAID patients do not show phenotypes consistent wi...

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Detalles Bibliográficos
Autores principales: Piché, Jessica, Gosset, Natacha, Legault, Lisa-Marie, Pacis, Alain, Oneglia, Andrea, Caron, Maxime, Chetaille, Philippe, Barreiro, Luis, Liu, Donghai, Qi, Xioyan, Nattel, Stanley, Leclerc, Séverine, Breton-Larrivée, Mélanie, McGraw, Serge, Andelfinger, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369230/
https://www.ncbi.nlm.nih.gov/pubmed/30739867
http://dx.doi.org/10.1016/j.jcmgh.2018.10.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369230/
https://www.ncbi.nlm.nih.gov/pubmed/30739867
http://dx.doi.org/10.1016/j.jcmgh.2018.10.011

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