Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria

Energy metabolism has recently gained interest as a target space for antibiotic drug development in mycobacteria. Of particular importance is bedaquiline (Sirturo), which kills mycobacteria by inhibiting the F(1)F(0) ATP synthase. Other components of the electron transport chain such as the NADH deh...

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Detalles Bibliográficos
Autores principales: Lee, Bei Shi, Kalia, Nitin P., Jin, Xin Er F., Hasenoehrl, Erik J., Berney, Michael, Pethe, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369303/
https://www.ncbi.nlm.nih.gov/pubmed/30530783
http://dx.doi.org/10.1074/jbc.RA118.005732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369303/
https://www.ncbi.nlm.nih.gov/pubmed/30530783
http://dx.doi.org/10.1074/jbc.RA118.005732

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