Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models

BACKGROUND: The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline. The A3 adenosine receptor (A3AR) is the only adenosine subtype overexpressed in inflammator...

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Detalles Bibliográficos
Autores principales: Kim, Yumi, Kwon, So Young, Jung, Hong Soo, Park, Yoo Jung, Kim, Yong Shin, In, Jang Hyeok, Choi, Jin Woo, Kim, Jin A, Joo, Jin Deok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Anesthesiologists 2019
Materias:
Experimental Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369348/
https://www.ncbi.nlm.nih.gov/pubmed/29969887
http://dx.doi.org/10.4097/kja.d.18.00022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369348/
https://www.ncbi.nlm.nih.gov/pubmed/29969887
http://dx.doi.org/10.4097/kja.d.18.00022

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