Efflux Inhibitor Bicalutamide Increases Oral Bioavailability of the Poorly Soluble Efflux Substrate Docetaxel in Co-Amorphous Anti-Cancer Combination Therapy

Many anti-cancer drugs are difficult to formulate into an oral dosage form because they are both poorly water-soluble and show poor permeability, the latter often as a result of being an intestinal efflux pump substrate. To obtain a more water-soluble formulation, one can take advantage of the highe...

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Detalles Bibliográficos
Autores principales: Bohr, Adam, Nascimento, Thais Leite, Harmankaya, Necati, Weisser, Johan Juhl, Wang, Yingya, Grohganz, Holger, Rades, Thomas, Löbmann, Korbinian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369428/
https://www.ncbi.nlm.nih.gov/pubmed/30642009
http://dx.doi.org/10.3390/molecules24020266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369428/
https://www.ncbi.nlm.nih.gov/pubmed/30642009
http://dx.doi.org/10.3390/molecules24020266

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