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An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin
N-nitroso-containing small molecules, such as the bacterial natural product streptozotocin, are prominent carcinogens(1,2) and important cancer chemotherapeutics(3,4). Despite this functional group’s significant impact on human health, dedicated enzymes involved in N-nitroso assembly have not been i...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369591/ https://www.ncbi.nlm.nih.gov/pubmed/30728519 http://dx.doi.org/10.1038/s41586-019-0894-z |