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Chromatin features constrain structural variation across evolutionary timescales
The potential impact of structural variants includes not only the duplication or deletion of coding sequences, but also the perturbation of noncoding DNA regulatory elements and structural chromatin features, including topological domains (TADs). Structural variants disrupting TAD boundaries have be...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369792/ https://www.ncbi.nlm.nih.gov/pubmed/30659153 http://dx.doi.org/10.1073/pnas.1808631116 |